Multi-slice spiral CT findings of primary pulmonary lymphoma / 中国医师进修杂志

Objective To summarize the imaging features of multi-slice spiral CT (MSCT) in primary pulmonary lymphoma (PPL),in order to provide effective imaging diagnostic basis for clinical diagnosis.Methods The MSCT findings of 11 patients with PPL in Dalian Municipal Friendship Hospital from January 2010 to March 2019 were retrospectively analyzed.Results Among the 11 patients,pulmonary non-Hodgkin lymphoma was in 9 cases,of which pulmonary mucosa-associated lowgrade marginal zone B-cell lymphoma (MALT lymphoma) was in 7 cases,pulmonary diffuse large B-cell lymphoma (DLBCL) was in 2 cases,and pulmonary Hodgkin lymphoma was in 2 cases.Single lesion was in 2 cases,and multiple lesions was in 9 cases.Nodules and mass type was in 6 cases,solid type in 2 cases,interstitial type in 1 case,and mixed type was in 2 cases.Consolidations with air bronchogram was in 6 cases,ground-glass opacity like nodules in 3 cases,angiogramsign in 4 cases,perilymphatic and/or peribronchovascular spread in 4 cases,and lymphadenopathies were in 2 cases.Conclusions Although the imaging diagnosis of primary lung lymphoma is difficult,MSCT has certain characteristics,and improving the identification of corresponding signs has certain guiding significance for clinical practice.

Effects of erythropoietin administrated by intranasal on nerve function and CD31 in cerebral ischemia reperfusion rats / 中华行为医学与脑科学杂志

Objective To explore the protective effect of erythropoietin(EPO) administrated by intranasal on cerebral ischemia reperfusion in rats with acute cerebral infarction reperfusion.Methods Total of 100 SD rats were divided into model control group,sham operation group,intraperitoneal administration group ([PEPO group),nasal saline group (INNS group) group,and nasal drug delivery group (INEPO group) with 20 in each group.The middle cerebral artery occlusion model of rat was established by thread embolism method and the NSS method was used to evaluate the neural behavior of rats.The expression of EPO in peripheral blood,cerebrospinal fluid and brain regions of rats were detected by Elisa.The vascular endothelial growth factor(VEGF) in brain was detected by immunofluorescence and then the density of newborn blood vessels in the brain was measured.Results Fifteen days after the operation,the NSS score of INEPO group(3.80± 1.61) was significantly lower than that of IPEPO group (11.53±2.11),and the difference was statistically significant(P＜0.01).And the levels of EPO in blood,cerebrospinal fluid and different brain regions of rats in INEPO group were higher than that of INNS group(all P＜0.01).Compared with IPE-PO group,the level of EPO cerebrospinal fluid and different brain regions of rats in INEPO group increased obviously,the difference was statistically significant (all P＜0.01),and the EPO concentration of the olfactory bulb was the most obvious (INEPO group:(1 456.90 ± 128.22) pg/ml,IPEPO group:(426.11 ± 36.68)pg/ml,P＜0.01).Seventy-two hours after operation,the expression of CD31 in ischemic penumbra of rats of model control group (18.21 ± 3.45),INNS group (18.54 ± 2.58),IPEPO group (27.01 ± 2.13) and INEPO group(35.52±2.79)was increased compared with sham operation group (5.14± 1.28),and the difference was statistically significant (all P＜0.05).The expression of CD31 in IPEPO group and INEPO group was significantly higher than that in INNS group (P＜0.05).In INEPO group,the expression of CD31 increased significantly compared with that of IPEPO group (P＜0.05).Conclusion Nasal administration of EPO can effectively improve the neurological function of rats with ischemia-reperfusion,and increase the expression of CD31 in the brain tissue of rats.The effect of nasal administration is better than that of intraperitoneal administration.

A Survey of Allergic Rhinitis among College Students in Kunming / 昆明医科大学学报

Objective To investigate the distribution,epidemiologic feature and the related risk features of allergic rhinitis among college students in Kunming.Methods Stratified cluster sampling was conducted in each school as a unit.The investigated subjects included 1500 students aged from18 to 29 years old from 7 universities in Kunming,Yunnan Province.The epidemiological investigation was carried out using the designed questionnaire of allergic rhinitis.The results were analyzed.Restlts We had given out 1500 questionnaires and the response rate was 98.9％.The self-reported prevalence of allergic rhinitis was 25.4％ among college students in Kunming,in which,the males' prevalence rate was 29.3％ and the females' was 22.9％.And 3.7％ of the students with allergic rhinitis were combined with asthma and the 19.1％ combined with a history of familial inheritance.The main risk factor was dust.Concltsion The self-reported and prevalence of allergic rhinitis among college students in Kunming is 25.4％.Males' prevalence rate is slightly higher than the females'.The potential risk factors are bronchial asthma and the history of familial inheritance.The mainly inducement is dust,animal fur and plant pollen.

Relationship among allergic rhinitis, regional pollens and meteorological conditions in Kunming area / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>To evaluate the species, quantity and diffusion of allergenic pollens as well as the relationship among allergic rhinitis (AR), pollen species and meteorological conditions in Kunming area.</p><p><b>METHODS</b>The exposure film was used to investigate the species of airborne pollen, the total number of these pollens during December 2009 to November 2010 by means of gravitational sedimentation, at the same time, AR patients were registered. The species of allergic pollen in Kunming area during the same period, and the statistic analysis was made with the meteorological elements, using the correlation analysis methods of Excel for data analysis.</p><p><b>RESULTS</b>From December 2009 to November 2010, a total of 60 exposure films of pollen species was found, including 26 147 pollens. The annual airborne pollen showed two scattering peak, respectively: February to April and September to October; the number of advantage pollen was 17 species. The number of year-round drifting pollen was 13 species while 2 species showed two peaks on spring and autumn. There was another 26 new species added to the results of 2009-2010, compared with 1987-1989, while the original 12 species were not seen. The drifting peak was the same. The number of allergen intradermal tests (AIT) positive AR patients was positively correlated with 16 pollen species, respectively, oleaceae, alnus nepalensis, walnut, palm, pig weed, fennel, Amaranthaceae, artemisia, rosa, Albizia julibrissin Durazz, gramineae, castor, Fraxinus L, populus, Morus alba L, hemp humulus, (r value were 0.689 7, 0.550 1, 0.742 1, 0.755 2, 0.771 2, 0.663 3, 0.556 1, 0.568 3, 0.659 8, 0.607 4, 0.834 7, 0.664 3, 0.745 9, 0.634 7, 0.718 3, 0.777 2, all P < 0.05). The population of AIT positive AR patients was positively correlated with average temperature, average wind speed and other meteorological factors (r values were 0.552 0, 0.883 5, both P < 0.05), and was negatively correlated with average relative humidity (r = -0.714 7, P < 0.05).</p><p><b>CONCLUSIONS</b>Kunming had a large number of airborne pollen species which showed two peaks annually, respectively, spring and autumn. The relationship among the number of AIT positive AR patients, the meteorological factors and the number of airborne pollen were close.</p>

Short-term efficacy of standardized medication offer chronic rhinosinusitis / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To evaluate the efficacy of standardized medication for patients with chronic rhinosinusitis.@*METHOD@#According to the diagnosis and treatment guidelines on chronic rhinosinusitis formulated in 2008, by means of prospective study, we studied 54 patients suffering from chronic rhinosinusitis treated with standardized medication including, a combination of local intranasaI corticosteroids, macrolides, mucus discharging agent and nasal irrigation treatment and followed up for 3 months. Visual analogue scale (VAS), sino nasal outcome test-20 Chinese version scales (SNOT-20 CV), Lund-Mackay CT and Lund-Kennedy endoscopy methods were employed to conduct the subjective and objective assessment and comprehensively evaluate the clinical efficacy before and after treatment.@*RESULT@#(1) After three months of standardized medication, the patients' total scores of VAS, SNOT-20 CV, CT and endoscopy were improved significantly compared with those before-treatment (P < 0.01 for all these scoring systems). (2) There was statistically significant difference between the clinical efficacies of chronic rhinosinusitis patients with and without nasal polyps groups (P < 0.01). After 3 months of standardized medication, the effective rates of the CRSwNP group evaluated by subjective assessment and CT evaluation were 66.7% and 94.4% respectively, while those of the CRSsNP groups were 91.7% and 97.2% respectively. (3) Betwecn CRSwNP and CRSsNP groups, there was no significant difference in the improvement rate or inefficiency rate in subjective assessment except for the cure rate, while there were significant differences in both cure rate and improvement rate in CT evaluation. (4) The CRS patients' self-testing-based questionnaires results showed positive correlation with objective assessments.@*CONCLUSION@#The standardized medication with combination of intranasal local glucocorticoid, macrolides (14-membered ring), the mucus discharging agent and nasal irrigation on CRS was effective.

Prevalence of sensitization to aeroallergens in 1 893 patients with allergic rhinitis in Yunnan / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate which aeroallergens were prevalent in patients with allergic rhinitis in Yunnan.@*METHOD@#Retrospective analysis of the medical records of intradermal test performed in 1893 AR patients. The samples were divided into four age groups: 4-17-year-olds, > 17-35-year-olds, > 35-50-year-olds and > 50-70-year-olds. According to gender,the samples were decided into two groups: the males and the females. The positive rate of aeroallergens were compared among the groups.@*RESULT@#(1)The total positive rate of intradermal test was 70.1%. The top ten allergens were as follow: dermatophagoides pteronyssinus, dermatophagoides farina, house dust, pollen of the summer and autumn, alnus nepalensis, chenopodiaceae, mugwort, poaceae, brassica and cockroach. (2) In all groups,patients with triple positive allergens were the most common,followed by dual positive allergens and single positive allergen. (3) Among the top ten allergens, the top three positive ones in all groups were dermatophagoides pteronyssinus, dermatophagoides farina and house dust. And there were significant differences between 4-17-year-olds group and the other age groups (P < 0.01). (4) There was no significant difference between male and female patients in distribution of aeroallergens except House dust and mite.@*CONCLUSION@#The most common allergen in patients with allergic rhinitis in Yunnan is mite,the follow are pollen of the summer and autumn, alnus nepalensis, chenopodiaceae, mugwort, poaceae, and brassica. The distribution of aeroallergens are different among the age groups, but has no evident correlation with gender.

Promotive effect of neovascularization on rats with cerebral infarction by intranasal administration of granulocyte colony-stimulating factor / 中华行为医学与脑科学杂志

Objective To study the promotive effect of neovascularization on rats with cerebral infarction by nasal administration of granulocyte colony-stimulating factor.Methods A blinded,vehicle-controlled study of ING-CSF and IHG-CSF administration was performed by intraluminal middle cerebral artery occlusion (MCAO) model.All Sprague-Dawley rats were randomly divided into sham-operation group,model group,INNS group,IHGCSF group and ING-CSF group.The neurologic behavioral tests were assessed after reperfusion 72 h.Mter 72 h of MCAO,the brains of rats were stainned with TTC and the infarcted volume was calculated by computer image analysis.The expression of vascular endothelial growth factor (VEGF) in the brain was determined by immune-histochemistry.The density of angiogenesis in the brain was counted under fluorescence microscope.Results The score of neurological function of ING-CSF group(3.90± 1.65)was improved significantly compared with the IHG-CSF group (10.55±2.19) at the point of 72 h after cerebral infarction (P＜0.01).The cerebral infarct volume of ING-CSF group((20.01±3.29) ％) was reduced evidently compared with the IHG-CSF group((33.48±4.49) ％) at 72 h (P＜ 0.01);while the cerebral infarct volume of INNS group ((60.20±7.72) ％)was not markedly different compared with the model group((61.49±6.41)％) at 72 h (P＞0.05).The expression of VEGF in the brains of ING-CSF group was significantly higher than other groups at 72 h.Conclusion Intranasal administration G-CSF can improve neurological function and vascular angiogenesis in rats following MCAO.

The value of multi-slice spiral CT angiograhy in resectable assessment of pancreatic carcinoma / 重庆医科大学学报

Objectives:To evaluate the clinical value of multi-slice spiral CT angiography(MSCTA)in the preoperative assessment ofvascular involvement and resectability of pancreatic carcinoma.Methods:Forty-eight cases of pancreatic carcinoma confirmedby surgical pathology were retrospectively analyzed.The state of peripancreatic vessels encroached by pancreatic carcinoma and the resectability were compared between MSCTA and routine axial images;16-slice spiral CT and dual Source CT.Results:For the assessment of resectability and peripancreatic vessel invaded by pancreatic carcinoma,dual source CT was better than 16-slice spiral CT;MSCT angiography was better than routine axial images.Conclusion:MSCT angiography technique can well display the delicate relation between tumor and vessels from different directions,and can delineate the vascular involvement of pancreatic carcinoma with high accuracy.It provides valuable information in the preoperative assessment of pancreatic carcinoma.